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Health and Wellness: Research
Pharmaceuticals
Greater Boston Area, East Coast, New England
Valo Health, Inc (Valo) is a technology company focused on utilizing large scale data and AI-driven computation to discover and develop therapeutics. Valo aims to fully integrate human-centric data across the entire drug development life cycle into a single unified architecture, thereby accelerating the discovery and development of life-changing drugs while simultaneously reducing costs, time, and failure rates. The company’s Opal Computational Platform™ is an end-to-end drug discovery and development platform with a unified architecture designed to transform data into valuable insights that may accelerate discoveries and enable Valo to advance a robust pipeline of programs, initially focused on cardiovascular metabolic renal, oncology, and neurodegenerative disease. Founded by Flagship Pioneering and headquartered in Boston, MA, Valo also has offices in Lexington, MA, and New York, NY.
Clinical Trials
San Francisco, California, United States
Unlearn.AI is a biotech AI company that develops a digital twin service for clinical trials. Digital twins enhance healthcare by assessing health risks before a disease manifests its symptoms, according to some experts. Unlearn brings together a world-class team of experts across pharma, medtech, machine learning, and business who share a vision of using machine learning and biostatistics to improve clinical trials for the benefit of patients and sponsors. Unlearn invented their TwinRCT solution to enable biopharma partners to run faster, more successful clinical trials. A TwinRCT is a randomized trial that uses machine learning to achieve a higher probability of success with a smaller number of patients. As in a traditional RCT, patients are randomized to a treatment group and a control group, but, unlike a traditional trial, a prognostic digital twin is created for every patient using a machine learning model trained on historical data. The treatment effects for the primary and secondary outcomes can all be estimated from the trial with greater precision after correcting for a prognostic score derived for each patient's digital twin. TwinRCTs provide a scientifically-sound method for using deep learning and historical patient data to improve clinical trials.
Clinical Trials
San Francisco, California, United States
Triomics is helping cancer care providers by reducing the burden associated with manually reviewing patient charts. The company advances oncology research and care operations by aiding in the acceleration of trial enrollment, quality improvement projects, and the streamlining of healthcare operations, among other functions. Its trusted and validated foundational oncology AI, trained to comprehend health records and medical terminology, underpins this critical mission.
Clinical Trials
Culver City, California, United States
TORL BioTherapeutics is a clinical-stage biopharmaceutical business focused on creating innovative, antibody-based medicines to improve the lives of cancer patients. They are developing a comprehensive pipeline of innovative preclinical ADCs and mAb in oncologic diseases with high unmet medical needs.
Clinical Trials
San Jose, California, United States
Lykos Therapeutics' goal is to revolutionize the way mental health is addressed. By creating innovative medicines and therapeutic techniques to treat mental health disorders, we hope to upend the status quo. With over thirty years of expertise investigating therapies aided by psychedelics, we continue to be committed to adhering to rigorous science so that we can create and market innovative treatment alternatives.
Clinical Trials
Pasadena, California, United States
Deep 6 AI is a computer software company that utilizes an AI-based platform that finds patients for clinical trials and it helps to provide cure to people. Its platform specializes in analyzing structured data, such as ICD-10 codes, unstructured clinical data, doctor’s notes, pathology reports, and operating notes. The company was founded in 2015 and headquartered in Pasadena, California.
Clinical Trials
Boston, Massachusetts, United States
Lindus Health is a clinical research organization running clinical trials. Their services include ethics, IRB submission, trial monitoring, data management, biostatistics, regulatory, and payor affairs. They also provide EDC, database, site, and feasibility products.
Information Technology
Palo Alto, California, United States
doc.ai is developing A.I. technologies to collect structured and real-world medical data to create engaging products, accelerate medical research and transform approaches to care. Their poly-omics data pipeline handles all forms of medical data to make it ready for analysis and model building. The company's primary consumer offering is a medical research companion app for personal-omics collection and digital health trials where participants can earn financial rewards. Additionally, they license A.I. modules and create products for a portfolio of clients, including payors, pharma, providers and patient organizations.
Clinical Trials
El Segundo, California, United States
We believe clinical research can be built to improve health equity globally. Learning if treatments are safe and effective for the people who need them requires us to offer studies that are more accessible and offer choice. We founded Lightship in 2018 with the inspiration to keep people at the heart of our work and use the latest innovations in digital health, technology, and remote care melded with high quality clinical research to transform clinical trials.
Biotechnology
Philadelphia, Pennsylvania, United States
Tmunity Therapeutics is developing novel products to unleash the immunological potential of T cells to treat a wide range of disease indications. Tmunity is developing novel T Cell Receptor (TCR) engineered T cells, regulatory T cells (Treg), and universal engineered T cell platforms that exhibit best-in-class control over T cell activation and direction in vivo, as well as proprietary technologies to activate, expand, and genetically engineer T cells from peripheral blood, cord blood and tumors. The company is rapidly advancing toward the clinic personalized next-generation immunotherapies for oncology, infectious diseases and autoimmune disease. The founding team includes experts in T-cell biology, manufacturing, regulatory affairs, and clinical development, who collectively have an unparalleled track record of executing safe and effective cell and gene therapy clinical trials. In addition, Tmunity’s manufacturing platform has a proven track record of success in supporting multi-center clinical studies across diverse therapeutic indications.
Clinical Trials
San Francisco, California, United States
Power Life Science believes that every patient deserves the chance to participate in a life-changing clinical trial. Is backed by some of the best healthcare investors and operators with a range of experience across clinical research and biopharmaceuticals. We are a small team - each of us with our own personal story and motivation to make a difference in the lives of patients.
Information Technology
Santa Clara, California, United States
Avail is a digital healthcare company providing a dedicated procedure room hardware/software platform with telepresence and software hosting capabilities. The complete Avail system enables the MedTech industry and healthcare providers to work together more often and more efficiently, harnessing expertise and technology in and out of the operating room to accelerate the innovation, adoption, and reach of tools and techniques to improve patient care. The company was founded in 2017 and is based in Silicon Valley, California.
Clinical Trials
New York, New York, United States
Massive Bio, is an Artificial Intelligence (AI) powered platform that connects cancer patients and their treating oncologists to clinical trials while enabling pharmaceutical companies to get access to patients, mostly in community practices, and their information to speed up drug development. Massive Bio combines technology, services and oncology sub-specialist expertise to maximize trial enrollment. Massive Bio is the first company that attacks controlling patient enrollment value chain; Massive Bio does patient identification through direct direct and indirect patient acquisition channels, pre-screening through virtual site, Just-In-Time (JIT) site activation and further analyzes real world data for drug discovery. One of the major differentiating point of Massive Bio is that the Company tackles “last mile†issues for trial enrollment to eliminate site and/or financial considerations of patients. Massive Bio is the go to partner for pharmaceutical companies and CROs to get the right patient at the right time.
Clinical Trials
San Francisco, California, United States
Curebase builds a digital clinical trial assistant that would alter how medical providers discover, activate, and administer clinical trials for their patients. It aims to run clinical trials faster and cheaper than anyone else via software that reduces recruitment times, automates manual steps, and lets drug companies distribute their trials to clinics. The company was established in 2017 and is based in San Francisco, California.
Clinical Trials
Cambridge, Massachusetts, United States
Repertoire Immune Medicines is a clinical stage biotechnology company working to unleash the human immune system to prevent, treat or cure cancer, autoimmune conditions and infectious diseases. The company is currently conducting experimental medicine clinical trials using autologous T cells primed against cancer antigens and tethered to IL-15.
Biotechnology
Wilmington, Delaware, United States
Synnovation Therapeutics is a precision oncology company focused on small molecule therapies optimized to target key driver mechanisms in cancers. It is dedicated to the discovery and development of therapeutics that can improve the lives of people with cancer. Leveraging its deep expertise in medicinal chemistry, cancer biology, and patient-focused precision medicine, it builds a diverse pipeline of novel small-molecule targeted therapies. It aims to efficiently advance these agents into clinical trials with the goal of transforming cancer patient care.
Information Technology
Somerset, New Jersey, United States
WhizAI is the first and only AI-powered analytics platform purpose-built for life sciences and healthcare. It puts insights directly into the hands of business users empowering decision-makers to drive more informed and faster business decisions at lower cost. With its deep understanding of the life sciences and healthcare domains and user intent, the platform delivers insights without the delays of traditional BI dashboards. Fast, easy, and scalable, WhizAI is transforming analytics with artificial intelligence optimized for life sciences and healthcare making WhizAI the trusted partner of choice at top global companies. Simply ask a question about sales, market access, patient services, or clinical trials -- and WhizAI answers it instantly. WhizAI's conversational interface allows users to simply talk to the enterprise data giving them complete autonomy to drill into every level of detail along with real-time updates. WhizAI’s advanced machine learning algorithms scan entire data sets to deliver proactive alerts and automatically surface anomalies, easily pinpointing stagnating sales, market share changes, patient drop-offs and much more. WhizAI enjoys nearly 100% adoption by business users, contributes to a 60% reduction in calls to IT and a 50% reduction in operational overhead within the first few months of implementation.
Clinical Trials
Wilmington, North Carolina, United States
Topography Health encourages physicians in private practice to participate in clinical trials in order to advance medical research. Topography assists medical practices in better understanding their patient populations, recommending which studies are likely to be taken up and have an impact, recruiting patients, and hiring and managing research staff. Topography-powered local clinical trials give patients with a wide range of health conditions access to personalized clinical trials for the first time.
Information Technology
Cambridge, Massachusetts, United States
OpenEvidence Information overload is a common problem in many high-value domains. It's a huge challenge in medicine. With such a rate of change, it is practically impossible for the world's physicians, medical scientists, and healthcare professionals to keep up with and comprehend all of the most recent research literature and clinical evidence pertinent to their work. Our contribution to the global effort to tame the medical information firehose is OpenEvidence: Artificial intelligence is applied in our strategy to aggregate, synthesize, and visualize clinical evidence in intelligible, clinically valuable formats that can be exploited.
Biotechnology
Seattle, Washington, United States
Juno is a clinical-stage company that brings together three of the world's leading cancer centers “ Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center and Seattle Children's Research Institute“ in unique partnership to advance a broad pipeline of breakthrough immunotherapies. With one of the largest ever Series A investments for a biotech startup, Juno will build on the foundation of novel immunotherapies to develop two distinct and complementary platforms “ CARs and TCRs.
Biotechnology
Philadelphia, Pennsylvania, United States
Innervace is a developer of a regenerative therapy company designed to develop implantable tissue-engineered brain pathways for neurodegenerative disorders. The company is focused on the development and commercialization of anatomically inspired living scaffolds for brain pathway reconstruction, and its lead clinical product is a tissue-engineered nigrostriatal pathway that mimics the lost nigrostriatal pathway in patients with Parkinson's disease. This gives patients access to technology that specifically reconstructs brain pathways rather than just masking symptoms temporarily. Innervace was established in 2018 by in Philadelphia, Pennsylvania
Information Technology
Syracuse, New York, United States
MedTech facilitates a community of professionals that works towards the development of bioscience and medical technology industry. It offers opportunities that enable its members to connect and collaborate with others in the industry for education and advocacy. MedTech facilitates a website that enables its members to find news and information about its events. It facilitates events, including MedTech Annual Conference, MedTech Annual Members' Dinner, MedTech Metro, and more. Furthermore, it facilitates MedTech Institute that offers training and certification programs. MedTech was founded in 2004 and is based in Syracuse, New York.
Biotechnology
Charlotte, North Carolina, United States
Vital Motion is a medical device company that conducted its own proprietary home-clinical study using prototype devices. The company is a manufacturer and marketer specifically targeting noninvasive, non-pharma methods of relieving symptoms of currently incurable chronic conditions and diseases such as fibromyalgia and chronic fatigue syndrome, and utilizing research and clinical data on the relationship and role of the soleus muscle in improving blood circulation and perfusion of vital organs. Vital Motion’s principal product is the VM-100 Hummingbird, a non-invasive mechanical stimulation device designed to stimulate contraction of the soleus muscles. By using the VM-100 Hummingbird twice daily for 10 to 30 minutes per session, the soleus muscle is stimulated potentially reducing many symptoms associated with fibromyalgia (FM) and chronic fatigue syndrome.
Biotechnology
Reston, Virginia, United States
We're on a journey to help find a cure for hair loss. An unparalleled biotech and bioinformatics company pioneering research to prevent hair loss from chemotherapy, pattern baldness, and alopecia. We're harnessing the power of synthetic biology and technologies such as nanotechnology, synthetic data artificial intelligence, and next generation sequencing to help detect and prevent the spread of molecular cells that cause and proliferate hair loss.
Biotechnology
Berkeley, California, United States
Organ Preservation Alliance (OPA) is a non-profit that enables breakthroughs in organ transplants and long term organ and tissue preservation by building and funding a thriving ecosystem of the world's top scientific and medical teams, and and an alliance of organ transplant and tissue banking organizations.
Information Technology
Reading, Massachusetts, United States
Health eVillages, a program of the not-for-profit Robert F. Kennedy Center for Justice & Human Rights and Physicians Interactive, provides state-of-the-art mobile health technology including medical reference and clinical decision support resources to medical professionals in the most challenging clinical environments around the world.
Information Technology
Woburn, Massachusetts, United States
C2I is an incubator and accelerator for life sciences. They provide life science entrepreneurs a place to call home and all the resources critical for them to conduct proof-of-concept research and develop their inventions into future commercial products. They enable a collaborative environment that allows thought-sharing and creative exchange.
Biotechnology
Palo Alto, California, United States
Inceptive designs RNA molecules using large-scale deep learning in a tight loop with high-throughput experiments. They create tools to develop increasingly powerful biological software for the rational design of novel, broadly accessible medicines and biotechnologies previously out of reach.
Biotechnology
Seattle, Washington, United States
ProfoundBio is a clinical-stage biotechnology company focused on the development of novel antibody-based therapeutics with curative potential for patients with cancer. Built on internally developed, innovative, and proprietary technology platforms, ProfoundBio has developed a pipeline consisting of multiple antibody-drug conjugate (ADC) drug candidates targeting solid tumors and hematological malignancies that are in discovery, preclinical, and clinical development stages.
Biopharmaceuticals
South San Francisco, California, United States
Insitro is an operator of a data-driven drug discovery and development company that utilizes machine learning and high-throughput biology to transform the way that drugs are discovered and delivered to patients. The company uses state-of-the-art technologies from bioengineering enabling it to generate high-throughput, functional genomic data sets and aligning them with patient data via novel machine learning methods, thereby building predictive models that can accelerate target selection and the design and development of effective therapeutics. In 2018, Daphne Koller established Insitro in South San Francisco, California..
Biopharmaceuticals
Hayward, California, United States
Eikon Therapeutics is a biopharmaceutical company employing revolutionary technology at the interface of biology, engineering, and chemistry to discover novel treatments for life-threatening diseases. Eikon'™s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes that enable real-time, molecular-resolution measurements of protein movement in living cells.
Biotechnology
San Francisco, California, United States
Altos Labs is a biotechnology company focused on cellular rejuvenation programming to restore cell health and resilience, with the goal of reversing disease to transform medicine. The company comprises a community of leading scientists, clinicians, and leaders from both academia and industry working together towards this common mission. Altos has operations in the San Francisco Bay Area and San Diego, and in Cambridge, UK, with significant collaborations in Japan.
Information Technology
Palo Alto, California, United States
Hippocratic AI develops safety-focused large language models with a focus on non-diagnostic, patient-facing applications. The majority of language models undergo pre-training using the common crawl of the Internet, which might contain inaccurate and deceptive information. In contrast, Hippocratic AI is significantly prioritizing the acquisition of evidence-based healthcare content through legal means, setting it apart from these language models.
Biotechnology
Mountain View, California, United States
Athelas develops technology to monitor chronically ill patients in their homes. The company has deployed an FDA-cleared blood diagnostic device along with an array of other sensors to manage Blood Pressure, Weight, Glucose, and Medication Adherence.
Clinical Trials
San Francisco, California, United States
Unlearn.AI is a biotech AI company that develops a digital twin service for clinical trials. Digital twins enhance healthcare by assessing health risks before a disease manifests its symptoms, according to some experts. Unlearn brings together a world-class team of experts across pharma, medtech, machine learning, and business who share a vision of using machine learning and biostatistics to improve clinical trials for the benefit of patients and sponsors. Unlearn invented their TwinRCT solution to enable biopharma partners to run faster, more successful clinical trials. A TwinRCT is a randomized trial that uses machine learning to achieve a higher probability of success with a smaller number of patients. As in a traditional RCT, patients are randomized to a treatment group and a control group, but, unlike a traditional trial, a prognostic digital twin is created for every patient using a machine learning model trained on historical data. The treatment effects for the primary and secondary outcomes can all be estimated from the trial with greater precision after correcting for a prognostic score derived for each patient's digital twin. TwinRCTs provide a scientifically-sound method for using deep learning and historical patient data to improve clinical trials.
Biotechnology
South San Francisco, California, United States
Cellares develops the Cell Shuttle, to overcome the challenges associated with manufacturing so these life-saving therapies are affordable and widely available to patients who can benefit. The clinical impact of cell therapy in treating cancer has been proven, but this therapeutic approach has several limitations, especially in manufacturing, leaving extremely sick patients waiting for treatment and desperate for hope. Since cell therapy is currently produced for a single patient at a time, it is expensive to manufacture, requiring significant time and resources, and is difficult to scale. Preclinical and clinical scientists, as well as commercial cell therapy manufacturers also lack the options to fully automate their manufacturing process quickly, safely, cost-effectively, and at the scale they need. The Cell Shuttle is an automated and closed end-to-end manufacturing solution that is flexible and scalable, enabling customers to run exact processes specified for their cell therapy. Compared with the current manual manufacturing processes for cell therapy, the Cell Shuttle'™s next-generation automated manufacturing solution has 10 times the scalability (meaning 10 times more patient doses can be produced simultaneously), enables a three-fold reduction in process failure rates, and will reduce the per-patient manufacturing cost by up to 70 percent for most processes.
Biotechnology
Philadelphia, Pennsylvania, United States
Proscia develops a digital pathology platform to assist routine pathology operations, enhance cancer diagnosis, and improve patient outcomes. Its platform utilizes computing technologies that unlock hidden data not visible to the human eye and turns that data into valuable insights to help physicians accelerate the development of life-saving advances.
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